Bikunin Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Induction in Macrophages
نویسندگان
چکیده
منابع مشابه
Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages.
Bikunin, a Kunitz-type protease inhibitor, exhibits anti-inflammatory activity in protection against cancer and inflammation. To investigate the molecular mechanism of this inhibition, we analyzed the effect of bikunin on tumor necrosis factor alpha (TNF-alpha) production in human peripheral mononuclear cells stimulated by lipopolysaccharide (LPS), an inflammatory inducer. Here, we show the fol...
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We reported previously that a reorganization of microfilaments can be observed when macrophages are stimulated with lipopolysaccharide (LPS). This reorganization is not detected with current methods in macrophages of an LPS-nonresponsive C3H/HeJ mouse. These results suggest that the observed microfilament response might be involved in a macrophage-activating process induced by LPS. To investiga...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2004
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cdli.11.6.1140-1147.2004